Two drone missiles hit a vehicle on the outskirts of the town of Mudiyah in Abyan province, killing all four people inside, Yemen security official said Thursday.
The dawn bombardments killed four suspected Al-Qaeda operatives in south Yemen where U.S has intensified air raids on jihadists.
The air bombardments comes two weeks after U.S President Donald Trump's administration reportedly gave the CIA new powers to conduct drone strikes against extremist targets in the Middle East.
Since March 2, U.S has launched dozens of air strikes against Al-Qaeda in the Arabian Peninsula (AQAP) targets in Abyan and the neighbouring provinces of Shabwa and Baida killing dozens of terror operatives.
In the first three days of the air raids at least 22 AQAP operatives were killed according to security officials and tribal sources.
U.S regards AQAP as the jihadist network's most dangerous arm and says that in recent months it has been plotting attacks on the West.